Oncometabolite L-2-Hydroxyglutarate Promotes Oncogenesis of Renal Cell Carcinomas by Down-Regulating Differentiation
L-2-Hydroxyglutarate (L2HG) overproducing Renal Cell Carcinomas (RCCs) arise in the kidney due to the genetic loss of L-2HG Dehydrogenase (L2HGDH), the enzyme responsible for the metabolism of L2HG. The overproduced 2-Hydroxyglutarate (2HG) promotes tumorigenesis by inhibiting α-ketoglutarate (αKG)-...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2022
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/85118 |
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