Recent Developments in Application of Multiparametric Flow Cytometry in CAR-T Immunotherapy
In recent years, chimeric antigen receptor (CAR) modified T-cell (CAR-T) immunotherapy has achieved great success in cancer treatment, especially in some hematologic malignancies. Multiparametric flow cytometry (MFC) is a key immunologic tool and plays an important role in every step of CAR-T design...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
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IntechOpen
2023
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/85752 |
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| Sumario: | In recent years, chimeric antigen receptor (CAR) modified T-cell (CAR-T) immunotherapy has achieved great success in cancer treatment, especially in some hematologic malignancies. Multiparametric flow cytometry (MFC) is a key immunologic tool and plays an important role in every step of CAR-T design, development, and clinical trials. This chapter discusses the application and new developments of MFC in CAR-T, including the selection of CAR-T targets, the enrollment of patients, the detection of minimal/measurable residual disease (MRD), the quality evaluation of CAR-T product, the detection of immune cell subsets and cytokines, and the study of immune checkpoint and immune suppressive microenvironment. |
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| ISBN: | 978-1-80356-590-3 |
| DOI: | 10.5772/intechopen.108836 |