The Microbiota-Gut-Brain Axis: Tryptophan Metabolism and Potential Therapeutic Strategies
<p id="p1">Tryptophan is an essential amino acid. It is metabolized through two main pathways: the kynurenine pathway and the methoxyidol pathway. The intestinal microbiota has been identified as a modifier of the metabolism of tryptophan and its derived metabolites. The resulting metabolites can tr...
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| Autores principales: | , , , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/88819 |
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| Sumario: | <p id="p1">Tryptophan is an essential amino acid. It is metabolized through two main pathways: the kynurenine pathway and the methoxyidol pathway. The intestinal microbiota has been identified as a modifier of the metabolism of tryptophan and its derived metabolites. The resulting metabolites can trigger immune, metabolic, and neuronal effects, at the systemic and distant levels, as well as therapeutic specific and nonspecific targets. The reader reviewing this content will learn the importance of tryptophan biotransformation through metabolism and the host-microbiome complex, the formation of serotonin and kynurenine, the pathways of unwinding and the physiological effects of metabolites within the intestinal part, energy metabolism and neurotransmitters. The effects and pathologies that dysregulation may have with this metabolism will be reviewed, as well as the therapeutic targets and related drugs.</p> |
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| ISBN: | 978-0-85466-692-8 |
| DOI: | 10.5772/intechopen.113888 |