Epigenetics in Multiple Sclerosis-Related Cognition Impairment
<p id="p1">Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease that can result in various disabilities, including cognitive impairment. While the myelin sheath is traditionally considered the primary target, the gray matter of the cortex is also affected, contributing to cogn...
Guardado en:
| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/88988 |
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| Sumario: | <p id="p1">Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease that can result in various disabilities, including cognitive impairment. While the myelin sheath is traditionally considered the primary target, the gray matter of the cortex is also affected, contributing to cognitive dysfunction. This study explores the role of epigenetics in understanding the underlying pathological processes of MS and evaluates potential molecular patterns influencing cognition in MS patients. Epigenetics involves processes regulating gene expression in response to environmental stimuli, encompassing changes in DNA, histones, and microRNA without altering the nucleotide sequence. Understanding these epigenetic mechanisms may reveal new avenues for developing therapeutic interventions to manage cognitive dysfunctions in MS. Given the limited available data on the role of epigenetics in cognition in MS patients, this study aims to provide a comprehensive review of the existing literature on this subject.</p> |
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| ISBN: | 978-0-85014-411-6 |
| DOI: | 10.5772/intechopen.114166 |