Histone Deacetylases (HDACs) as Key Targets in Metabolic Disorders
<p id="p1">Metabolic disorders such as obesity, diabetes, cardiac hypertrophy, and atherosclerosis are linked to changes in diet, exercise, aging, and genetics. Nonetheless, several studies propose that other environmental factors and epigenetic regulations may also contribute remarkably to the rapi...
Guardado en:
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/89244 |
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| Sumario: | <p id="p1">Metabolic disorders such as obesity, diabetes, cardiac hypertrophy, and atherosclerosis are linked to changes in diet, exercise, aging, and genetics. Nonetheless, several studies propose that other environmental factors and epigenetic regulations may also contribute remarkably to the rapid increase in the prevalence of these metabolic diseases. Histone deacetylases/acylases (HDACs) are epigenetic regulators that mediate transcriptional regulations via the removal of acetyl/acyl functionalities from key lysine side chains of nucleosomal histones. Indeed, the dynamic interplay between the acetylation state (catalyzed by histone acetyltransferase (HATs) and the deacetylation state (catalyzed by HDACs) of histone lysine side chains is responsible for epigenetic control. Of interest, it has been recognized that HDACs play an important role in numerous diseases, which include aging and metabolic diseases, viz., cancer, cardiac disorders, fibrosis, diabetes, inflammation, and others. Therefore, targeting HDACs with small molecules could help treat metabolic disorders. This chapter provides an overview of the catalytic deacetylation mechanisms of HDACs, their role in metabolic disorders, and the prospects of HDAC inhibitors, activators, and proteolysis-targeting chimeras (PROTACs) in treating metabolic diseases. Toward this journey, an extensive literature search was conducted using the key phrase “HDACs and metabolic disorders” in Google Scholar and PubMed.</p> |
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| ISBN: | 978-0-85014-432-1 |
| DOI: | 10.5772/intechopen.114836 |