Impact of Plasminogen on <em>Clostridioides difficile</em> Colitis
<p id="p1">Pathogens often manipulate the host plasminogen activation system to facilitate escape from the initial site of infection, promote systemic invasion, and evade immune protection. Plasminogen, which is known for its involvement in fibrinolysis, immune modulation, and wound healing, has rec...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
|
| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/89486 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | <p id="p1">Pathogens often manipulate the host plasminogen activation system to facilitate escape from the initial site of infection, promote systemic invasion, and evade immune protection. Plasminogen, which is known for its involvement in fibrinolysis, immune modulation, and wound healing, has recently been linked to <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Clostridioides difficile</italic></em> spore germination. By identifying the mechanisms that drive spore germination and their contribution to <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">C. difficile</italic></em> pathogenesis, in animal model studies, we gain insights into their role in disease severity and mortality. Moreover, inhibiting plasminogen activation using a specific single-chain variable fragment (scFv) has shown the potential to reduce infection severity and mortality. These findings suggest that targeting plasminogen-mediated pathways can be a promising therapeutic approach for managing <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">C. difficile</italic></em> colitis.</p> |
|---|---|
| ISBN: | 978-0-85014-468-0 |
| DOI: | 10.5772/intechopen.115060 |