Marine-Derived Novel Compounds for Fibrinolysis
<p id="p1">Marine-derived natural compounds play a major role in treating several human-related diseases due to their unique chemical diversity, biocompatibility, and excellent medicinal properties. Recent studies have explored the potential of marine organisms, especially microorganisms, as sources...
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| Autores principales: | , , , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/89527 |
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| Sumario: | <p id="p1">Marine-derived natural compounds play a major role in treating several human-related diseases due to their unique chemical diversity, biocompatibility, and excellent medicinal properties. Recent studies have explored the potential of marine organisms, especially microorganisms, as sources for novel bioactive substances that possess fibrinolytic activity. For the past decades, our team has been exploring marine-derived secondary metabolites as novel compounds for thrombolysis and fibrinolysis. Our recent studies investigated the fibrinolytic properties of Fungi fibrinolytic compound(R)-2,5-bis(2R,3R)-2-((E)-4,8-dimethylnona-3,7-dien-1-yl)-3,5-dihydroxy-2-methyl-7-oxo-3,4,7,9-tetrahydropyrano[2,3-e]isoindol-8(2H)-yl)pentanoic acid (Fungi fibrinolytic compound-1 (FGFC1), staplabin) with a molecular weight of 869 Da from a rare marine microorganism <em><italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">Stachbotrys longispora</italic></em> FG216. Accordingly, this chapter highlights the source of bioactive compounds, especially FGFCs from different marine organisms. We review the extraction methods and characteristics of these bioactive compounds and their molecular signaling mechanisms and examine their role in fibrinolysis and related disorders.</p> |
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| ISBN: | 978-0-85014-468-0 |
| DOI: | 10.5772/intechopen.115095 |