Molecular, Pharmacologic and Biochemical Aspects of Polycarbonate Plastic Bisphenol Exposures
<p id="p1">Bisphenol acetone was initially studied for potential application as an estrogen substitute, and since then, it is in industrial use as dually-substituted bifunctional epoxide in epoxy resins and as poly-BPA ester carbonate for its elasticity and advanced material bend properties. The bis...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
|
| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/89773 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | <p id="p1">Bisphenol acetone was initially studied for potential application as an estrogen substitute, and since then, it is in industrial use as dually-substituted bifunctional epoxide in epoxy resins and as poly-BPA ester carbonate for its elasticity and advanced material bend properties. The bisphenols are lipophilic chemicals with hydrophilic substituents and steroid nucleus structure that can bind to cell surface and nuclear receptors to exert pituitary, thyroid and steroid axis, and adipose tissue / end organ-related health effects. The available bisphenols utilized in industry are known and have been characterized for their binding affinity by traditional assays such as saturation (-Ka) and competition (IC<sub>50</sub>), and reporter-based transfectant assay for study of their agonist (EC<sub>50</sub>) or antagonist (IC<sub>50</sub>) potential. The bisphenol A / BP receptors include the NR adapters, Ncor1, Smrt and Ncoa1-7 (Src), and the coadapter binding partners, Erα and Erβ, Gpr30 and Errγ, Rorα, Pparγ, and by effect on coadapter, TRα and TRβ. Dose-potency-efficacy concentration modeling is applicable to the study of NOAEL, LOAEL, ED<sub>50</sub> and LD<sub>50</sub> effects in population health and ecological studies. In this chapter, the sustentative knowledge on bisphenol properties, biochemical pathways, gene activation and repression, and epigenetics, is covered with meditation on cell-based receptor binding assays and potency-efficacy curvilinear relationships relevant to the epidemiology of exposure assessment.</p> |
|---|---|
| ISBN: | 978-1-83769-297-2 |
| DOI: | 10.5772/intechopen.115284 |