Molecular Test for Tuberculous Meningitis Early Diagnosis
<p id="p1">Tuberculous meningitis (TBM) is one of the most challenging clinical diagnoses of extrapulmonary tuberculosis. TBM is considered a severe neurological emergency with risks of complications and severe neurological sequelae. Neurological complications can develop early in the course of the...
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| Autores principales: | , |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2025
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/89775 |
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| Sumario: | <p id="p1">Tuberculous meningitis (TBM) is one of the most challenging clinical diagnoses of extrapulmonary tuberculosis. TBM is considered a severe neurological emergency with risks of complications and severe neurological sequelae. Neurological complications can develop early in the course of the disease or paradoxically during treatment. TBM is a paucibacillary infection, decreasing the sensitivity of diagnostic tests. Different laboratory assays have been implemented to improve the rapid laboratory diagnosis of TBM with phenotypic, immunological, and molecular tests. The rapid molecular test for tuberculosis early diagnosis and drug resistance leads to effective therapy, which influences its outcome in patients with TBM. Treatment delays have been associated with increased morbidity, mortality, and spread of tuberculosis. Unfortunately, the best combination of drugs and doses has not been established, the best duration of treatment is not defined, and mortality is high despite effective anti-tuberculous treatment.</p> |
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| ISBN: | 978-0-85014-456-7 |
| DOI: | 10.5772/intechopen.115599 |