Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle
Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete classification of paratuberculosis immunopathological types in cattle re...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Consejo Superior de Investigaciones Científicas, CSIC: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
2014
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| Acceso en línea: | https://dialnet.unirioja.es/servlet/oaiart?codigo=4952217 |
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| Sumario: | Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis
and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete
classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031
slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim
of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof
of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological
evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology
of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis
epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and
might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could
become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with
multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate
epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion
of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while
patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals. |
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