Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle
Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete classification of paratuberculosis immunopathological types in cattle re...
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Consejo Superior de Investigaciones Científicas, CSIC: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)
2014
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| author | Vázquez, Patricia Garrido Urkullu, Joseba M. Molina, Elena Geijo Vázquez, María V. Gómez, Nieves Pérez Pérez, Valentín Sevilla Agirregomoskorta, Iker Alonso Hearn, Marta Cortés Alonso, Mª Adoración Juste Jordán, Ramón Antonio |
| author_browse | Alonso Hearn, Marta Cortés Alonso, Mª Adoración Garrido Urkullu, Joseba M. Geijo Vázquez, María V. Gómez, Nieves Juste Jordán, Ramón Antonio Molina, Elena Pérez Pérez, Valentín Sevilla Agirregomoskorta, Iker Vázquez, Patricia |
| author_facet | Vázquez, Patricia Garrido Urkullu, Joseba M. Molina, Elena Geijo Vázquez, María V. Gómez, Nieves Pérez Pérez, Valentín Sevilla Agirregomoskorta, Iker Alonso Hearn, Marta Cortés Alonso, Mª Adoración Juste Jordán, Ramón Antonio |
| author_sort | Vázquez, Patricia |
| building | Dialnet |
| collection | Acceso abierto |
| description | Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis
and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete
classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031
slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim
of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof
of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological
evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology
of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis
epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and
might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could
become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with
multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate
epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion
of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while
patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals. |
| first_indexed | 2026-10-16T04:39:58Z |
| format | Article |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>dialnet-ART0000733413</identifier><datestamp>2024-08-16</datestamp><dc:title>Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle</dc:title><dc:creator>Vázquez, Patricia</dc:creator><dc:creator>Garrido Urkullu, Joseba M.</dc:creator><dc:creator>Molina, Elena</dc:creator><dc:creator>Geijo Vázquez, María V.</dc:creator><dc:creator>Gómez, Nieves</dc:creator><dc:creator>Pérez Pérez, Valentín</dc:creator><dc:creator>Sevilla Agirregomoskorta, Iker</dc:creator><dc:creator>Alonso Hearn, Marta</dc:creator><dc:creator>Cortés Alonso, Mª Adoración</dc:creator><dc:creator>Juste Jordán, Ramón Antonio</dc:creator><dc:subject>bovine paratuberculosis</dc:subject><dc:subject>immunopathology</dc:subject><dc:subject>microbiology</dc:subject><dc:subject>epidemiology</dc:subject><dc:subject>pathogenesis</dc:subject><dc:subject>latency</dc:subject><dc:description>Paratuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis
and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete
classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031
slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim
of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof
of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological
evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology
of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis
epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and
might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could
become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with
multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate
epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion
of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while
patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals.</dc:description><dc:publisher>Consejo Superior de Investigaciones Científicas, CSIC: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)</dc:publisher><dc:date>2014</dc:date><dc:type>text (article)</dc:type><dc:format>application/pdf</dc:format><dc:identifier>https://dialnet.unirioja.es/servlet/oaiart?codigo=4952217</dc:identifier><dc:identifier>(Revista) ISSN 2171-9292</dc:identifier><dc:identifier>(Revista) ISSN 1695-971X</dc:identifier><dc:source>Spanish journal of agricultural research, ISSN 1695-971X, null 12, Nº. 4, 2014, pags. 1049-1060</dc:source><dc:language>eng</dc:language><dc:rights>LICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI</dc:rights></oai_dc:dc> |
| id | dialnet-ART0000733413 |
| institution | Dialnet |
| language | eng |
| last_indexed | 2026-10-16T04:39:58Z |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Consejo Superior de Investigaciones Científicas, CSIC: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) |
| publisherStr | Consejo Superior de Investigaciones Científicas, CSIC: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) |
| record_format | oai_dc |
| spelling | dialnet-ART00007334132024-08-16Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattleVázquez, PatriciaGarrido Urkullu, Joseba M.Molina, ElenaGeijo Vázquez, María V.Gómez, NievesPérez Pérez, ValentínSevilla Agirregomoskorta, IkerAlonso Hearn, MartaCortés Alonso, Mª AdoraciónJuste Jordán, Ramón Antoniobovine paratuberculosisimmunopathologymicrobiologyepidemiologypathogenesislatencyParatuberculosis is a chronic mycobacterial infection causing granulomatous enteritis in ruminants, whose pathogenesis and epidemiology poses numerous challenges, including latency and reactivation. The most recent and complete classification of paratuberculosis immunopathological types in cattle recognized five categories. In this study, 1031 slaughtered Friesian cattle were submitted to serological, microbiological and pathological examinations with the aim of maximizing the rate of case detection. In most cases, infected animals had minimal lesions and almost no other proof of infection (38.9%), while the more characteristic types with the whole constellation of microbiological and immunological evidences accounted for a lower proportion (7.7%). As these findings in cattle suggest similarities with the epidemiology of tuberculosis in humans, we propose to re-group the original immunopathological types into two broader paratuberculosis epidemio-pathogenic forms or states: latent and patent. The former term would define infections with focal lesions and might constitute an apparent resilience status representing a difficult to detect reservoir of infection whose role could become critical if later immune-compromising factors lead to re-activation. The latter would group those cases with multifocal and diffuse inflammatory lesions with higher mycobacterial load and viability suggestive of a more immediate epidemiological risk. Interestingly, the relative frequency of presentation of each profile varied with age. The proportion of latent forms remained relatively constant between 33.8% and 54.3% through adulthood from 3 years of age, while patent forms were more frequent during the first years of age and tended to decrease among the oldest individuals.Consejo Superior de Investigaciones Científicas, CSIC: Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)2014text (article)application/pdfhttps://dialnet.unirioja.es/servlet/oaiart?codigo=4952217(Revista) ISSN 2171-9292(Revista) ISSN 1695-971XSpanish journal of agricultural research, ISSN 1695-971X, null 12, Nº. 4, 2014, pags. 1049-1060engLICENCIA DE USO: Los documentos a texto completo incluidos en Dialnet son de acceso libre y propiedad de sus autores y/o editores. Por tanto, cualquier acto de reproducción, distribución, comunicación pública y/o transformación total o parcial requiere el consentimiento expreso y escrito de aquéllos. Cualquier enlace al texto completo de estos documentos deberá hacerse a través de la URL oficial de éstos en Dialnet. Más información: https://dialnet.unirioja.es/info/derechosOAI | INTELLECTUAL PROPERTY RIGHTS STATEMENT: Full text documents hosted by Dialnet are protected by copyright and/or related rights. This digital object is accessible without charge, but its use is subject to the licensing conditions set by its authors or editors. Unless expressly stated otherwise in the licensing conditions, you are free to linking, browsing, printing and making a copy for your own personal purposes. All other acts of reproduction and communication to the public are subject to the licensing conditions expressed by editors and authors and require consent from them. Any link to this document should be made using its official URL in Dialnet. More info: https://dialnet.unirioja.es/info/derechosOAI |
| spellingShingle | bovine paratuberculosis immunopathology microbiology epidemiology pathogenesis latency Vázquez, Patricia Garrido Urkullu, Joseba M. Molina, Elena Geijo Vázquez, María V. Gómez, Nieves Pérez Pérez, Valentín Sevilla Agirregomoskorta, Iker Alonso Hearn, Marta Cortés Alonso, Mª Adoración Juste Jordán, Ramón Antonio Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle |
| title | Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle |
| title_full | Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle |
| title_fullStr | Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle |
| title_full_unstemmed | Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle |
| title_short | Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle |
| title_sort | latent infections are the most frequent form of paratuberculosis in slaughtered friesian cattle |
| topic | bovine paratuberculosis immunopathology microbiology epidemiology pathogenesis latency |
| url | https://dialnet.unirioja.es/servlet/oaiart?codigo=4952217 |
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