Emerging Trends in Sickle Cell Disease and CRISPR/Caspases
<p id="p1">In this review chapter, sickle cell disease (SCD) overview, its diagnostic procedures and markers to date as well as the proposed model or pathways by which SCD oxidative stress activates caspases leading to a shrunken sickle cell are presented. Of the various approaches used to mitigate...
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| Autor principal: | |
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Acceso en línea: | https://www.intechopen.com/chapters/1181663 |
| Etiquetas: |
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| Sumario: | <p id="p1">In this review chapter, sickle cell disease (SCD) overview, its diagnostic procedures and markers to date as well as the proposed model or pathways by which SCD oxidative stress activates caspases leading to a shrunken sickle cell are presented. Of the various approaches used to mitigate SCD effects, it is anticipated that the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Caspases could possibly edit the sixth position alteration on the β-globin gene on chromosome 11. Even though CRISPR/Caspases hold promise in sickle cell disease in the near future, it is also possible for it to create genomic chaos. Here, several schools of thought are presented as well.</p> |
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| ISBN: | 978-0-85466-920-2 |
| DOI: | 10.5772/intechopen.1004305 |