Emerging Trends in Sickle Cell Disease and CRISPR/Caspases
<p id="p1">In this review chapter, sickle cell disease (SCD) overview, its diagnostic procedures and markers to date as well as the proposed model or pathways by which SCD oxidative stress activates caspases leading to a shrunken sickle cell are presented. Of the various approaches used to mitigate...
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| Formato: | Capítulo de libro |
| Lenguaje: | inglés |
| Publicado: |
IntechOpen
2024
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| Materias: | |
| Acceso en línea: | https://www.intechopen.com/chapters/1181663 |
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| _version_ | 1879164840511012864 |
|---|---|
| author | Ababio, Grace K. |
| author_browse | Ababio, Grace K. |
| author_facet | Ababio, Grace K. |
| author_sort | Ababio, Grace K. |
| building | IntechOpen |
| collection | Acceso abierto |
| description | <p id="p1">In this review chapter, sickle cell disease (SCD) overview, its diagnostic procedures and markers to date as well as the proposed model or pathways by which SCD oxidative stress activates caspases leading to a shrunken sickle cell are presented. Of the various approaches used to mitigate SCD effects, it is anticipated that the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Caspases could possibly edit the sixth position alteration on the β-globin gene on chromosome 11. Even though CRISPR/Caspases hold promise in sickle cell disease in the near future, it is also possible for it to create genomic chaos. Here, several schools of thought are presented as well.</p> |
| doi_str_mv | 10.5772/intechopen.1004305 |
| first_indexed | 2026-10-15T21:40:44Z |
| format | Book Chapter |
| fullrecord | <oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><identifier>intech-1181663</identifier><datestamp>2024-04-02</datestamp>
<dc:title>Emerging Trends in Sickle Cell Disease and CRISPR/Caspases</dc:title>
<dc:creator>Grace K. Ababio</dc:creator>
<dc:subject>Health Sciences</dc:subject>
<dc:description><p id="p1">In this review chapter, sickle cell disease (SCD) overview, its diagnostic procedures and markers to date as well as the proposed model or pathways by which SCD oxidative stress activates caspases leading to a shrunken sickle cell are presented. Of the various approaches used to mitigate SCD effects, it is anticipated that the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Caspases could possibly edit the sixth position alteration on the &beta;-globin gene on chromosome 11. Even though CRISPR/Caspases hold promise in sickle cell disease in the near future, it is also possible for it to create genomic chaos. Here, several schools of thought are presented as well.</p></dc:description>
<dc:publisher>IntechOpen</dc:publisher>
<dc:date>2024-04-02</dc:date>
<dc:type>Chapter, Part Of Book</dc:type>
<dc:identifier>https://www.intechopen.com/chapters/1181663</dc:identifier>
<dc:identifier>doi:10.5772/intechopen.1004305</dc:identifier>
<dc:language>en</dc:language>
<dc:relation>ISBN:978-0-85466-920-2</dc:relation>
<dc:rights>https://creativecommons.org/licenses/by/3.0/</dc:rights>
<dc:source>https://www.intechopen.com/books/1002959 ; Current Practices in Sickle Cell Disease</dc:source>
</oai_dc:dc> |
| id | intech-1181663 |
| institution | IntechOpen |
| isbn | 978-0-85466-920-2 |
| language | English |
| last_indexed | 2026-10-15T21:40:44Z |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | IntechOpen |
| publisherStr | IntechOpen |
| record_format | oai_dc |
| spelling | intech-11816632024-04-02 Emerging Trends in Sickle Cell Disease and CRISPR/Caspases Grace K. Ababio Health Sciences <p id="p1">In this review chapter, sickle cell disease (SCD) overview, its diagnostic procedures and markers to date as well as the proposed model or pathways by which SCD oxidative stress activates caspases leading to a shrunken sickle cell are presented. Of the various approaches used to mitigate SCD effects, it is anticipated that the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Caspases could possibly edit the sixth position alteration on the β-globin gene on chromosome 11. Even though CRISPR/Caspases hold promise in sickle cell disease in the near future, it is also possible for it to create genomic chaos. Here, several schools of thought are presented as well.</p> IntechOpen 2024-04-02 Chapter, Part Of Book https://www.intechopen.com/chapters/1181663 doi:10.5772/intechopen.1004305 en ISBN:978-0-85466-920-2 https://creativecommons.org/licenses/by/3.0/ https://www.intechopen.com/books/1002959 ; Current Practices in Sickle Cell Disease |
| spellingShingle | Health Sciences Ababio, Grace K. Emerging Trends in Sickle Cell Disease and CRISPR/Caspases |
| title | Emerging Trends in Sickle Cell Disease and CRISPR/Caspases |
| title_full | Emerging Trends in Sickle Cell Disease and CRISPR/Caspases |
| title_fullStr | Emerging Trends in Sickle Cell Disease and CRISPR/Caspases |
| title_full_unstemmed | Emerging Trends in Sickle Cell Disease and CRISPR/Caspases |
| title_short | Emerging Trends in Sickle Cell Disease and CRISPR/Caspases |
| title_sort | emerging trends in sickle cell disease and crispr caspases |
| topic | Health Sciences |
| url | https://www.intechopen.com/chapters/1181663 |
| work_keys_str_mv | AT ababiogracek emergingtrendsinsicklecelldiseaseandcrisprcaspases |